Computational Biology in Pediatric Kidney Disease
Tue, Aug 04
|Online Event
The Sampson Lab is passionate about using computational biology to discover the mechanisms by which APOL1 risk variants contribute to kidney disease, which disproportionately affects African Americans, to develop treatments and cures.
Time & Location
Aug 04, 2020, 12:00 PM – 1:15 PM EDT
Online Event
About the Event
APOL1 associated proteinuric disease (from sampsonlab.org)
Recently, two genetic variants in apolipoprotein L1 (APOL1), common in African-Americans, were found to result in greatly increased risk of FSGS and progression of chronic kidney disease in African-Americans. The mechanism of APOL1's kidney damage is unknown. Therefore, we are interested in the clinical impact that these risk variants have on African-Americans, both adults and pediatric patients.
Our lab has identified participants in the Nephrotic Syndrome Study Network (NEPTUNE) who harbor the high-risk APOL1 genotype and paired this information with molecular, histologic, and longitudinal clinical data to discover their clinical and transcriptomic implications. In 2016, we published this work in the Journal of the American Society of Nephrology (link). Furthermore, earlier this year we collaborated on a study of the role of APOL1 in pediatric patients specifically in a NEPTUNE and the Chronic Kidney Disease in Children Study (CKiD) (link). We continue to study APOL1-associated proteinuric…
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