#BlackInCompBio Seminar Series: Angela Brooks, Ph.D. & Alexis Thornton.

The Brooks laboratory focuses on the study of somatic mutations that cause changes to the transcriptome, particularly through mRNA splicing. They aim to gain a better understanding of how alternative splicing is regulated and the functional consequences of splicing dysregulation through the study of these cancer genome alterations. They are developing computational approaches to analyze genome and transcriptome sequencing data and developing high-throughput experimental approaches to characterize the functional impact of cancer variants.

Much of their work has been in collaboration with large national and international consortia including modENCODE, The Cancer Genome Atlas (TCGA), and the International Cancer Genome Consortium (ICGC).